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Wed 30 January 2013

Identification of Reference Genes for Quantitative RT-PCR in ascending aortic aneurysms

Posted by Dr. Carlos Porras. This article was posted in Cirugía Cardiaca and tagged with aorta, genes, bicuspid, aneurysm, cardiac surgery, ascending aortic aneurysm, publication, Journal PLos One

We reproduce the summary of the recently published paper in the Journal PLoS One (Public Library of Science One) by, among others, Dr. Porras and Prof. Schäfers.

«Identification of Reference Genes for Quantitative RT-PCR in Ascending Aortic Aneurysms»

Dominic Henn, Doris Bandner-Risch, Hilja Perttunen, Wolfram Schmied, Carlos Porras, Francisco Ceballos, Noela Rodriguez-Losada, Hans-Joachim Schäfers

PLoS One. 2013;8(1):e54132. doi: 10.1371/journal.pone.0054132. Epub 2013 Jan 11.

Hypertension and congenital aortic valve malformations are frequent causes of ascending aortic aneurysms. The molecular mechanisms of aneurysm formation under these circumstances are not well understood. Reference genes for gene activity studies in aortic tissue that are not influenced by aortic valve morphology and its hemodynamic consequences, aortic dilatation, hypertension, or antihypertensive medication are not available so far. This study determines genes in ascending aortic tissue that are independent of these parameters.

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