Acceso de los editores

Wed 30 January 2013

Identificación de "genes de referencia" mediante RT-PCR cuantitativa en aneurismas de aorta ascendente

Posted by Dr. Carlos Porras. This article was posted in Cirugía Cardiaca and tagged with bicúspide, aorta, aneurisma, genes, publicación, aneurismas de aorta ascendente, Journal PLos One
Reproducimos el resumen del artículo recientemente publicado en la revista PLoS One (Public Library of Science One) por el Dr. Porras y el Prof. Schäfers, entre otros autores

«Identification of Reference Genes for Quantitative RT-PCR in Ascending Aortic Aneurysms»

Dominic Henn, Doris Bandner-Risch, Hilja Perttunen, Wolfram Schmied, Carlos Porras, Francisco Ceballos, Noela Rodriguez-Losada, Hans-Joachim Schäfers

PLoS One. 2013;8(1):e54132. doi: 10.1371/journal.pone.0054132. Epub 2013 Jan 11.

plosonelogo.jpg

La hipertensión y las malformaciones congénitas de la válvula aórtica se asocian con frecuencia a los aneurismas de aorta. Los mecanismos moleculares de la formación de aneurismas en estas circunstancias no se conocen con profundidad. No se conocen “genes de referencia” para estudios de actividad génica en tejido aórtico que no estén influenciados por la morfología de la válvula aórtica y sus consecuencias hemodinámicas, por la dilatación aórtica, la hipertensión o la medicación antihipertensiva. Este estudio determina los genes presentes en el tejido de la aorta ascendente que son independientes de esos parámetros.


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Wed 30 January 2013

Identification of Reference Genes for Quantitative RT-PCR in ascending aortic aneurysms

Posted by Dr. Carlos Porras. This article was posted in Cirugía Cardiaca and tagged with aorta, genes, bicuspid, aneurysm, cardiac surgery, ascending aortic aneurysm, publication, Journal PLos One
We reproduce the summary of the recently published paper in the Journal PLoS One (Public Library of Science One) by, among others, Dr. Porras and Prof. Schäfers.

«Identification of Reference Genes for Quantitative RT-PCR in Ascending Aortic Aneurysms»

Dominic Henn, Doris Bandner-Risch, Hilja Perttunen, Wolfram Schmied, Carlos Porras, Francisco Ceballos, Noela Rodriguez-Losada, Hans-Joachim Schäfers

PLoS One. 2013;8(1):e54132. doi: 10.1371/journal.pone.0054132. Epub 2013 Jan 11.

plosonelogo.jpg

Hypertension and congenital aortic valve malformations are frequent causes of ascending aortic aneurysms. The molecular mechanisms of aneurysm formation under these circumstances are not well understood. Reference genes for gene activity studies in aortic tissue that are not influenced by aortic valve morphology and its hemodynamic consequences, aortic dilatation, hypertension, or antihypertensive medication are not available so far. This study determines genes in ascending aortic tissue that are independent of these parameters.


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Arrhythmias

The Arrhythmias Unit of the Heart Area cares for patients with heart rhythm disorders. It is divided into two specific areas.

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Marfan Unit

ICTA has the first Marfan unit set up in the private health sector in Spain: we diagnose, follow-up and treat Marfan syndrome patients.

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Modern Cardiac Surgery: coronary surgery with and without extracorporeal circulation, conventional valve surgery, etc.

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Our group has pioneered aortic valve replacement techniques. Our operating theatre is fully equipped for aortic root surgeries.

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